Know how

Custom process development for recombinant proteins

GTP has more than 15 years of experience in recombinant protein and monoclonal antibody production. We offer a unique combination of protein research culture and recognized expertise in process development. Our experts enjoy a good challenge and provide solutions to even the most challenging recombinant protein development projects.

Our expert scientists adapt the process to the protein. Not the other way around.

Vast experience with challenging recombinant protein projects 

When contemplating a development programme for an innovative or complex recombinant protein, one of the keys to success is understanding the unique challenge your specific protein presents.

The majority of CMOs and CDMOs who manufacture recombinant proteins for clinical trials and market supply are reluctant to take on process development projects that do not fall under a well-established standard.

Here at GTP, we have a vivid scientific interest in “non-conventional” protein development projects. Over the years, we have developed over 1200 protein projects, covering a wide range of proteins: enzymes, cytokines, growth factors, hormones, receptors, transcription factors… and achieved widespread recognition for our expertise in the development of upstream and downstream processes for challenging proteins.

Custom upstream and downstream processes

We believe that no single expression system is ideal for each and every protein. As a consequence, we work with a broad selection of expression systems to provide solutions on a case-by-case basis. We have acquired over 15 years of experience in all prominent industrial microbial, mammalian and insect cell expression systems such as E. coliP. pastoris, CHOHEK and Sf9.

Drawing on our track-record  and multi-IP free-system capability, we offer a science-based decision for system selection.

Through the diversity of proteins and customers GTP has worked with, our scientists have acquired the necessary agility to customise downstream processes for every specific case.

Seamless process transfer to manufacturing

Our unique focus is to develop the best process for your recombinant protein: we adapt the process to the protein, not the other way around.

To help you move forward, we will always share our vision and inform you on realistic expectations about your project. When established standards are not applicable, we  suggest innovative approaches, always with process transferability in mind. For a cost-effective and seamless transfer to the cGMP manufacturing suite of your choice, we use methods and platforms that are identical to those used by most CMOs.

Downstream development 2 Process development for complex proteins 2