Mammalian cell line development

GTP is your partner of choice for GMP compliant mammalian cell line development

GTP offers SMART cell line development services, to provide you with highly-producing and stable mammalian cell lines ready for transfer to GMP manufacturing.

SMART CHO Cell Line Development Service

We have developed a SMART CHO cell line development service that is very well adapted to biopharma companies with challenging molecules looking for a partner offering expertise, flexibility and guidance.
GTP provides a unique tailored approach for cell line development including adapted product quality analysis  at key points during clone selection to ensure that both product critical quality attributes and productivity targets are met.

smart cell line development

Efficient workflow for accelerated cell line development

RCB in 4 months

We use a well-established workflow for the cloning, transfection and selection of the top clones, allowing us to offer competitive timelines.
Our 2-step process includes a first selection of top parental clones followed by a limiting dilution assisted by a high-resolution imaging system.
In addition to providing an increased assurance of clonality, the advantage of this process is that we can, starting from the parental clones, offer an early preparation of non-GMP material and an accelerated start for process development for projects with significant time constraints.


Advantages of CHOvolution

GMP-compliant CHO platform

GTP's cell line development services use an established, robust and highly-performant technology: CHOvolution™.

The technology is based on a non-genetically modified CHO-K1 host cell line. The proprietary vector system  ensures that at least two copies of the expression cassette are inserted into the genome. Together with the use of a strong promoter, this guarantees a strong expression of the gene of interest.

Integrated process development services to support biotherapeutics development projects

Performing cell line development and process development under the same roof is a great asset for the success and timely completion of your project. GTP has extensive experience in the development of upstream, downstream and analytical methods and can take charge of your project up to its transfer to our privileged cGMP CMO partners.
 Our expert team will always focus on developing the best process for your specific molecule, in addition to providing valuable flexibility and guidance all through the project.

During the initial development steps, we offer solutions for a timely production of the material re-quired for your proof-of-concept and preclinical efficacy and tox studies, like our transient transfec-tion platform, in both HEK and CHO cells.

Process development and manufacturing compacte