We have successfully expressed a variety of proteins with P. pastoris
Pichia pastoris is one of the most extensively used systems for recombinant protein expression. The expiry of key patents, as well as emerging new technologies, open the door to considering this system for more types of proteins and applications, such as new antibody scaffolds.
Pichia's greatest advantage results from the combination of its high heterologous protein secretion capacity with its low levels of endogenous protein secretion, which leads to simplified downstream processes. In addition, since Pichia pastoris can be grown to high cell densities, resulting in high protein yields per litre of culture, this is a cost-efficient eukaryotic system.
We have successfully used Pichia system to express enzymes, cytokines, antibody-derived fragments…