P. pastoris

Long convinced that P. pastoris is a high-potential industrial platform for recombinant production, we have developed expertise with this system for many proteins and applications.

Our P. pastoris expression services aim at developing highly productive strains and processes

We have successfully expressed a variety of proteins with P. pastoris

Pichia pastoris is one of the most extensively used systems for recombinant protein expression. The expiry of key patents, as well as emerging new technologies, open the door to considering this system for more types of proteins and applications, such as new antibody scaffolds.

Pichia's greatest advantage results from the combination of its high heterologous protein secretion capacity with its low levels of endogenous protein secretion, which leads to simplified downstream processes. In addition, since Pichia pastoris can be grown to high cell densities, resulting in high protein yields per litre of culture, this is a cost-efficient eukaryotic system.

We have successfully used Pichia system to express enzymes, cytokines, antibody-derived fragments…

P. pastoris

We offer custom services for your evaluation of the P. pastoris  expression system

For the successful production of your recombinant protein in P. pastoris, we offer customised services that span the entire range from gene or sequence to highly productive expression strains and processes:

  • Generation of P. pastoris strain
  • Screening of high and hyper-producing clones
  • Development and optimisation of fed-batch fermentation strategies