Insect cell expression system for timely and cost-effective production
The popularity of the insect cell-baculovirus expression system lies in its ability to produce relatively large quantities of post-translationally modified eukaryotic proteins. Production only takes a relatively short period of time and can be completed at competitive production costs.
Since the system is lytic, it is suited for both intracellular and secreted proteins, and is ideal for protein projects with inhibitory or toxic effects on mammalian host cells.
For this reason, insect cell expression has been largely used for the production of a variety of target proteins. But this lytic feature is a limitation for industrial production, for which mammalian cells are still largely preferred, particularly for therapeutic projects.