Capabilities

Downstream process development

GTP offers solutions for the purification of even the most challenging recombinant proteins in order to provide high-quality downstream processes. Our expert team has over 15 years of experience in recombinant protein and antibody projects and uses a science-driven approach, based on protein science and its translation to process development.

Custom development of GMP-ready downstream processes for every specific protein

Customised purification process development for all your protein projects

GTP's downstream process development services cover the full development cycle of your protein or antibody project. We develop a custom approach for every single protein and antibody in order to meet your needs and goals.

For one-shot small production batches for your research or POC studies, we develop a purification scheme that ensures maximal purity and yield, using one or several purification tags whenever acceptable, for speed and cost reasons.

For protein and antibody projects that have reached a later stage in development, our scientists define the process that delivers the required purity and quality attributes, while ensuring process robustness, reproducibility and scalability.

Rarely-matched purification skills

With over 800 proteins produced, the GTP-team has developed rarely-matched purification skills. Our scientists consider that each protein presents a unique challenge when they develop its purification process. Thanks to our 15 years of experience with a diversity of proteins and customers, we have acquired the agility to customise downstream processes to each specific case.

GMP-ready downstream processes

For antibodies, we apply platform approaches to accelerate process development.

For proteins for which classic technologies are not applicable, we bring innovation into the process, with transferability always in mind.

Our team develops purification schemes from scratch, including the following downstream unit operations:

  • Clarification by frontal filtration or centrifugation
  • Tangential flow filtration
  • High pressure homogenisation
  • Precipitation, extraction, refolding
  • Chromatography purification applying a large set of media & supports
  • Nanofiltration, virus or product inactivation

 

Downstream development 1 Downstream development 2

The methods and platforms used when developing upstream processes for your recombinant protein are identical to those used by most CMOs, for a cost-effective and seamless transfer to the manufacturing suite of your choice.