Downstream process development

GTP offers solutions for the purification of even the most challenging recombinant proteins

Our experts in process development aim at developing processes that deliver the required purity and quality attributes, while ensuring process robustness, reproducibility and scalability.

Unique protein purification skills

Thanks to our 19 years of experience and over 800 proteins produced, our team has developed rarely-matched purification skills.

Our scientists consider that each protein presents a unique challenge and have the agility to customise downstream processes to each specific case.


GMP-ready downstream processes

For antibodies, we apply platform approaches to accelerate process development.

For proteins for which classic technologies are not applicable, we bring innovation into the process, with transferability always in mind.

Our team develops purification schemes from scratch, including the following downstream unit operations:

  • Clarification by frontal filtration or centrifugation
  • Tangential flow filtration
  • High pressure homogenisation
  • Precipitation, extraction, refolding
  • Chromatography purification applying a large set of media & supports
  • Nanofiltration, virus or product inactivation


Downstream development 1 Downstream development 2

The methods and platforms used when developing upstream processes for your recombinant protein are identical to those used by most CMOs, for a cost-effective and seamless transfer to the manufacturing suite of your choice.

Custom development of GMP-ready downstream processes for every specific protein