R&D

To achieve this, we aim to stay at the cutting edge of protein science and are running several in-house R&D programs.

One of these projects involves the development of an innovative expression system, LactXpress, based on the Lacococcus lactis bacterial strain which represents an alternative host system to E. coli for the production of high-added-value proteins and peptides.

We are also involved in several European interdisciplinary R&D programs with the aim of overcoming recombinant protein production-related bottlenecks.

• Type of Project: FP6-Integrated Project-Priority 3 ‘NMP'
• Duration: 48 Months (2006-2010)
• Participants:

1.Centro Ricerche FIAT (Italy), 2.Johnson Matthey plc (UK), 3.NV Bekaert S.A. (Belgium), 4.Aerosol and Particle Technology Laboratory – CERTH/CPERI (Greece), 5.Christian Doppler Laboratory for Applied Computational Thermofluidynamics (Austria), 6.Politecnico di Torino (Italy), 7.FH Koblenz University of Applied Science (Germany), 8.Institut National de la Sante et de la Recherche Medicale (France), 9.Ceramiques Techniques et Industrielles S.A. (France), 10.ATH Cleanair GmbH (Germany), 11.Stobbe Tech Ceramics A/S (Denmark), 12.Tech in Tex TEXTIL GMBH (Austria), 13.GTP Technology (France), 14.DUPONT (Luxembourg), 15.Pyrogenesis S.A. (Greece)

• Summary:

The objective of the ATLANTIS project is to develop the required knowledge base and component technologies in nanostructured porous media and apply them to the manufacture of:

- a highly efficient compact and multifunctional emission control system for lean-burn automotive engines (e.g. for Diesel powered engines)

- a high yield, continuous and compact bioreactor for the production of recombinant proteins and antibodies for pharmaceutical and bio-diagnostic applications.

To learn more...

• Call : FP7- KBBE-2007-2A – Activity : Novel Enzymes
• Duration: 48 Months (2009-2012)
• Participants :

1 Westfaelische Wilhelms Universitaet Muenster (Germany), 2. Intitut National de la Recherche Agronomique (France), 3. Centre National de la Recherche Scientifique (France), 4. Wageningen Universiteit (Netherlands), 5. Sveriges Lantbruksuniversitet (Sweden), 6. Bulgarian Academy of Sciences (Bulgaria), 7. Danisco A/S (Denmark), 8. Sanofi-Aventis Recherche & Developpement (France), 9. Gilet Chitosan EURL (France), 10. Geneart AG (Germany), 11. LibraGen (France), 12. ARTES Biotechnology GmbH (Germany), 13. GTP Technology (France), 14. Lyon Ingénierie Projets (France), 15. Petra Tewes-Schwarzer (Germany).

• Summary:

The PolyModE project convenes an international, interdisciplinary and intersectorial consortium to identify, characterise, and optimise novel polysaccharide modifying enzymes, and to develop robust fermentation strategies for their large-scale production, to exploit the potential of biopolymers for food, pharmaceutical, cosmetic, and technical applications.

To learn more www.polymode.eu

• Type of Project: Eurotrans-Bio Project
• Duration: 36 Months (2009-2011)
• Participants :

1. Inkoa Sistemas S.L. (Spain), 2. Université de Perpignan (France), 3. GTP Technology (France)

• Summary:

Within the group of marine biotoxins, the group of Okadaic Acid (OA) and its analogues represents a significant risk to public health due to its lipophilic character, heat stability (which means it cannot be destroyed by normal cooking, freezing or smoking) and risk of accumulation in filter feeders such as mussels, oysters, clams and scallops. The main goal of the BIOKA project is the design and development of biosensors based on reliable and robust methods for the fast detection of OA and its derivatives. 

• Detection of Anatoxin-a(s) in Environmental Samples of Cyanobacteria by Using a Biosensor with Engineered Acetylcholinesterases. Full text (PDF).
• Strategies to develop malic acid biosensors based on malate quinone oxidoreductase (MQO) Biosens Bioelectron. Full text (PDF).
• An improved biosensor for acetaldehyde determination using a bienzymatic strategy at poly (neutral red) modified carbon film electrodes. Full text (PDF).
• Low potential detection of NADH with Prussian Blue bulk modified screen-printed electrodes and recombinant NADH oxidase from Thermus thermophilus. Full text (PDF).

• Lactococcus lactis, an Efficient Cell Factory for Recombinant Protein Production and Secretion. Full text (PDF) .
• Complementation of the Lactococcus lactis secretion machinery with Bacillus subtilis SecDF Improves Secretion of Staphylococcal Nuclease. Full text (PDF).
• Production and purification of staphylococcal nuclease in Lactococcus lactis using a new expression -secretion system and a pH-regulated mini-reactor. Full text (PDF) .

• Molecular Characterization of Inflammation and Staphylococcus aureus Colonization of Involved Skin of Atopic Dermatitis Patients. Full text (PDF)