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GTP Technology has developed an innovative expression system, based on L. lactis bacterial strain. Thanks to its advantages, this systems represents an alternative to E. coli system for high added value recombinant proteins production
GTP TECHNOLOGY’S OFFER
Services :
GTP Technology performs comparison studies of L. lactis systems with other expression systems, establishes the best production conditions for your protein,…
Out-licensing :
For large scale productions of your recombinant therapeutic proteins.
WHY USE L.LACTIS ?
4 GOOD REASONS…
"Safe" system. "GRAS” (Generaly Recognized As Safe) and "endotoxin free" system.
Easy to use. Microbial host with rapid growth and very simple metabolism.
Easy to scale-up. Growth in stirred fermentors without aeration : scale up to thousands of liters in one step only.
Easy dowstream process. Efficient secretion of proteins and limited endogen proteins : the protein of interested is often more than 50% pure in the supernatant.
GTP TECHNOLOGY’S SYSTEM : PZN SYSTEM
> Proprietary expression vectors
A tightly controlled expression system, both highly inducible and well repressed for heterologous protein production
- Pzn promoter and Signal peptide Exp4
> "Protease Free" strain
Better stability of secreted proteins by deletion of the unique L. lactis extracellular protease
- Exclusive engineered strain HtrA
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